TB-500 Co
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Research compound, not FDA-approved

The human trials for TB-500 tested a different molecule

Thymosin beta-4 is a 43-amino-acid protein with 15 registered clinical trials behind it. TB-500 is a 7-amino-acid fragment of it, and FDA reports no human exposure data for the fragment at all. Every study on this site names the molecule that was actually administered, and the species it was given to.

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  • 2,143people enrolled in registered trials of the full 43-amino-acid protein
  • 0published human studies of the fragment that is actually in the vial
  • 26studies and registry records in our graded evidence table, each labelled by molecule and species
  • 11of those tested the TB-500 fragment; 10 of the 11 are animal, cell or product analyses
  • 55fetch-verified sources: 29 peer-reviewed, 26 government, registry or anti-doping authority

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Compounded injectable treatmentPrepared after approval
Catalog image. Dispensed product and packaging may vary by pharmacy.

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Important: Standalone TB-500 is not sold through this checkout. The available option is a BPC-157 / TB-500 blend.

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Prescription treatment requires an online medical evaluation. A provider will determine whether treatment is medically appropriate; approval is not guaranteed.

Key facts

  • StatusResearch compound, not FDA-approved
  • Human PK of the fragmentNone publishedsource
  • Human half-life of the fragmentNever measuredsource
  • Human bioavailability of the fragmentNever measured by any routesource
  • Rat metabolismAc-LK primary metabolite at 0-6 h; Ac-LKK detectable to 72 hsource
  • Active moiety in questionOnly the metabolite Ac-LKKTE showed significant wound-repair activity, not the parent peptidesource
  • Equine detectionParent and Ac-LK confirmed in plasma and urine after a single 10 mg subcutaneous dose; limits about 0.01 to 0.02 ng/mLsource
  • Surface adsorptionTB-500 is a published model peptide for loss to glassware and plasticware; stated concentration is not always delivered concentrationsource
  • Human PK of the full protein (different molecule)Dose-proportional exposure with half-life increasing with dose, at 42 to 1260 mg IVsource
  • ClassSynthetic 7-amino-acid peptide; the acetylated actin-binding fragment (residues 17-23) of thymosin beta-4Chemical referencesource
  • SequenceAc-LKKTETQ (Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln)Chemical referencesource
  • Molecular weight889.0 Da (C38H68N10O14), CAS 885340-08-9Chemical referencesource
  • Parent proteinThymosin beta-4: 43 amino acids, 4963 Da. A different molecule, about 5.6 times the massChemical referencesource
  • FDA human exposure dataNone identified by FDA for the fragmentAbsence of evidencesource
  • July 2026 PCACFDA proposed that TB-500 free base and TB-500 acetate NOT be added to the 503A compounding listRegulatory recordsource
  • WADA 2026Named under S2.3 as thymosin beta-4 and its derivatives; prohibited at all times; non-Specified SubstanceRegulatory recordsource
  • Published human studies of the fragment0. One phase 1/2 safety study is recruiting with no results postedAbsence of evidencesource
  • Participants in registered trials of the full protein2,143 across 15 completed or terminated trialsInternal measurementsource
  • Human pharmacokinetics of the fragmentNone published; no half-life, bioavailability or clearance measured in a personAbsence of evidencesource
  • Animal metabolismIn rats, Ac-LK dominates at 0-6 h; Ac-LKK detectable to 72 h; only the metabolite Ac-LKKTE showed wound-repair activityAnimal PKsource
  • Best-documented in vivo dose10 mg subcutaneously, in horses, administered by racing laboratories to build detection testsAnimal PKsource
  • Established human doseNone. No human dose-finding study has been publishedAbsence of evidencesource
  • Product contentAnalysis of marketed TB500 and TB1000 found content not systematically consistent with its descriptionsAnalytical studysource

Read the full TB-500 monograph

Browse by topic

Everything on TB-500, organised the way you research it.

Comparisons12 articlesEvidence10 articlesDosing10 articlesSafety9 articlesSourcing9 articles

Free TB-500 tools

Practical calculators and references, each scoped and sourced.

T-01TB-500 reconstitution calculatorConcentration, per-dose volume, U-100 syringe units and doses per vial, from vial size, diluent volume and dose mass.T-02TB-500 syringe unit and mass converterTwo-way conversion between mg, mcg, mL and U-100 insulin syringe units at a given concentration.T-03TB-500 study-dose explorerThe per-compound data component for this brand: every dose actually used in the published literature, filterable by molecule, species and route, each row linking its source. It is built around the distinction the rest of the market blurs, so the molecule filter is the first control, not a footnote.

All guides

50 in-depth, individually cited guides.

Comparisons 12 guides

TB-500 stacks: what the research actually supportsTB-500 is almost always paired with BPC-157 in practice. Here's what the preclinical record says about stacking it, and where the evidence stops.Updated 2026-07-25Read guide →
TB-500 vs BPC-157: how the two peptides actually differTB-500 vs BPC-157 compared: mechanisms, evidence quality, WADA status, and why most research protocols pair them instead of choosing one.Updated 2026-07-25Read guide →
TB-500 vs physical therapy: what the evidence actually showsTB-500 is preclinical and WADA-banned; physical therapy has decades of clinical data. Here's the honest head-to-head on evidence, risk, and what to actually do.Updated 2026-07-25Read guide →
TB-500 vs PRP: how the two repair therapies actually compareTB-500 is a preclinical peptide; PRP is an FDA-cleared blood product with real human trials. Here's the actual evidence gap, cost, and legal status.Updated 2026-07-25Read guide →
TB-500 vs thymosin beta-4: what's actually differentTB-500 is a synthetic fragment, not full thymosin beta-4. Both are preclinical, WADA-banned, and unapproved. Here's the actual study record.Updated 2026-07-25Read guide →
3 closely related:TB4 peptide vs TB-500: what's actually differentTB4 vs TB500 peptide: what's actually differentThymosin beta 4 vs tb 500: what's actually different
Best TB-500 capsules: buyer reality check before you orderLooking for the best TB-500 capsules? Injectable TB-500 has no oral bioavailability data. Here's what the study record actually shows before you buy.Updated 2026-07-24Read guide →
TB-4 vs TB-500: what's the actual difference?TB-4 (thymosin beta-4) is the native 43-amino-acid protein. TB-500 is a shorter synthetic fragment. Here's what the research record actually says about each.Updated 2026-07-24Read guide →
TB-500 vs GHK-Cu: how these two repair peptides differTB-500 and GHK-Cu both get used for tissue repair, but they work differently and neither has human trial data. Here's the actual comparison.Updated 2026-07-24Read guide →
TB-500 vs stem cell therapy: what the evidence actually showsTB-500 is a preclinical peptide sold as a research chemical. Stem cell therapy is a clinical procedure with real costs. Here's how the evidence compares.Updated 2026-07-24Read guide →

Evidence 10 guides

How long does TB-500 take to work?Honest timeline for TB-500 based on preclinical wound-healing data, since no human dosing trials exist. What the tissue-repair research actually shows.Updated 2026-07-25Read guide →
TB-500: what the peptide is and what research actually showsTB-500 explained: what it is, how it differs from thymosin beta-4, dosing patterns in research, the BPC-157 pairing, legal status, and WADA prohibition.Updated 2026-07-25Read guide →
TB-500 and athletes drug testing: what actually gets flaggedTB-500 is on WADA's prohibited list under S2. Here's how testing labs detect it, why it's banned, and what the peptide research actually shows.Updated 2026-07-25Read guide →
TB-500 before and after claims: what the evidence actually showsTB-500 before and after photos are anecdotal, not data. Here's what human and preclinical research actually says about healing timelines and outcomes.Updated 2026-07-25Read guide →
TB-500 clinical trials: what the actual research record showsThere are no completed human clinical trials on TB-500 itself. Here's what the preclinical and analytical chemistry record actually says, sourced study by study.Updated 2026-07-25Read guide →
TB-500 human studies: what the actual research showsNo published human trials test TB-500 directly. Here's what the peptide, doping, and orthopaedic literature actually says, and where the gaps are.Updated 2026-07-25Read guide →
TB-500 mechanism of action: what it actually does in tissueTB-500 is a synthetic Tβ4 fragment studied for actin binding and cell migration. Here's the real mechanism data, what's preclinical, and what's missing.Updated 2026-07-25Read guide →
TB-500 results: what the actual research showsTB-500 human trial data is basically zero. Here's what the preclinical and analytical chemistry research actually says, and what it doesn't.Updated 2026-07-25Read guide →
What does TB-500 actually do? The research record explainedTB-500 is studied preclinically for wound healing and tissue repair. Here's what the actual research shows, versus native thymosin beta-4, and what's still unproven.Updated 2026-07-25Read guide →
TB-500 animal studies vs human evidence: what's realTB-500 research is almost entirely rat, mouse, and horse data. Here's what the animal studies actually show and why human trials still don't exist.Updated 2026-07-24Read guide →

Dosing 10 guides

TB-500 cycle length: how long protocols actually runMost TB-500/BPC-157 cycles in forum and clinic use run 4-8 weeks. Here's what the human and animal data actually support, and where the numbers come from.Updated 2026-07-25Read guide →
TB-500 how to inject: reconstitution, sites, and techniqueHow TB-500 injections are actually done in the research literature: reconstitution, subcutaneous vs IM, sites, needle gauge, and what the studies don't cover.Updated 2026-07-25Read guide →
TB-500 injection sites: subcutaneous vs IM, by regionWhere researchers place TB-500/BPC-157 blend injections, subcutaneous vs intramuscular, rotation schedules, and why the evidence behind site choice is thin.Updated 2026-07-25Read guide →
TB-500 storage and shelf life: how to keep it stableTB-500 storage rules: lyophilized vials keep for years refrigerated or frozen; once reconstituted, cold storage and use within roughly 2-4 weeks is standard practice.Updated 2026-07-25Read guide →
TB-500 timeline: what to expect week by weekWhat actually happens on a TB-500 timeline, from injection to reported effects at week 2, 4, and beyond. Preclinical evidence, honestly labeled.Updated 2026-07-25Read guide →
How to reconstitute TB-500: a step-by-step protocol guideHow to reconstitute TB-500 (dispensed as a BPC-157/TB-500 blend): water type, volume math, storage, and what the actual study record does and doesn't support.Updated 2026-07-24Read guide →
TB-500 dosage: what the research record actually showsNo approved TB-500 dosage exists. Here's what preclinical and doping-control literature says about dose, timing, and why 10mg claims don't hold up.Updated 2026-07-24Read guide →
TB-500 dosage calculator: what the numbers actually meanA TB-500 dosage calculator can't replace real data. Here's how the math works, what studies actually used, and why the science is still preclinical.Updated 2026-07-24Read guide →
TB-500 half-life: what the actual data showsNo published human half-life exists for TB-500. Here's what the animal and lab data actually say, and why every dosing schedule online is guesswork.Updated 2026-07-24Read guide →
TB-500 reconstitution: the actual protocol, step by stepHow TB-500/BPC-157 blend vials get reconstituted: water volume, storage temp, shelf life, and the mistakes that ruin peptide potency before it's ever drawn up.Updated 2026-07-24Read guide →

Safety 9 guides

Does TB-500 need to be refrigerated? storage rules explainedYes, reconstituted TB-500 needs cold storage. Here's what the peptide-stability literature actually says about lyophilized vials, mixed solution, and shelf life.Updated 2026-07-25Read guide →
TB-500 and blood work: what actually shows up on labsNo standard panel flags TB-500. Here's what bloodwork can and can't tell you, what markers to track anyway, and why detection needs specialized MS methods.Updated 2026-07-25Read guide →
TB-500 contraindications: who should not use itTB-500 lacks human trials, so contraindications are inferred. See who should avoid it, drug interactions, WADA status, and why sourcing is unregulated.Updated 2026-07-25Read guide →
TB-500 drug interactions: what the research actually showsNo human interaction trials exist for TB-500. Here's what preclinical data, WADA rules, and orthopaedic peptide reviews say about mixing it with other drugs.Updated 2026-07-25Read guide →
TB-500 in women: what the research actually showsNo TB-500 studies isolate female subjects. Here's what the preclinical wound-healing data, dosing patterns, and safety gaps actually mean for women considering it.Updated 2026-07-25Read guide →
TB-500 purity and testing: what buyers actually need to checkNo standalone TB-500 exists as a compounded SKU. Here's what purity testing can and can't tell you, and why it's dispensed in a BPC-157/TB-500 blend.Updated 2026-07-25Read guide →
TB-500 side effects: what the research record actually showsTB-500 side effects come from mostly preclinical and forensic data, not human trials. Here's what's documented, what's unknown, and what WADA says.Updated 2026-07-25Read guide →
Is TB-500 safe? What the research actually showsIs TB-500 safe? Human trials don't exist. Here's what preclinical data, doping labs, and orthopedic reviews actually say about risk.Updated 2026-07-24Read guide →
TB-500 long term side effects: what the research actually showsNo published human trials track TB-500 past a few weeks. Here's what preclinical, forensic, and orthopedic research says about long-term risk and unknowns.Updated 2026-07-24Read guide →

Sourcing 9 guides

How to verify TB-500 quality before you inject anythingThere's no consumer test kit for TB-500 purity. Here's what a paper trail, a COA, and the actual research record can (and can't) tell you.Updated 2026-07-25Read guide →
Is TB-500 FDA approved? The direct answerNo. TB-500 has zero FDA-approved drug applications. Here's what its regulatory status actually is, what the research shows, and what that means for you.Updated 2026-07-25Read guide →
TB-500 certificate of analysis explained: what it provesA COA shows purity and identity, not FDA approval or that TB-500 is legal to sell as a drug. Here's what to actually check before you trust one.Updated 2026-07-25Read guide →
TB-500 cost and pricing: what it actually runs in 2026There's no standalone TB-500 SKU. Here's what a BPC-157/TB-500 blend actually costs, why prices vary so much, and what you're really paying for.Updated 2026-07-25Read guide →
TB-500 for sale: what you're actually buying, explainedSearching "TB-500 for sale"? No standalone SKU exists. Here's how it's actually dispensed, what the evidence shows, and the questions to ask before you buy.Updated 2026-07-25Read guide →
TB-500 legal status: what's actually legal to buy and useTB-500 is not FDA-approved, isn't on the 503A bulk list, and is WADA-banned in sport. Here's the real legal picture before you buy anything.Updated 2026-07-25Read guide →
Best tb500 peptide: what "best" actually means hereThere's no ranked list of TB-500 brands worth trusting. Here's what the research record actually says, and what to check before you buy anything.Updated 2026-07-24Read guide →
TB-500 compounding pharmacy vs research supplier: reality checkNo standalone TB-500 exists at a pharmacy. Here's what the 503A/503B rules actually allow, what research suppliers sell, and how to read the difference.Updated 2026-07-24Read guide →
TB-500 prescription requirements: what the law actually saysNo FDA-approved TB-500 exists, so there's no standard prescription. Here's how legal access actually works, and where the gray areas really are.Updated 2026-07-24Read guide →

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